منابع مشابه
CZH proteins: a new family of Rho-GEFs.
The Rho family of small GTPases are important regulators of multiple cellular activities and, most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain-containing proteins are the classical guanine nucleotide exchange factors (GEFs) responsible for activation of Rho GTPases. However, members of a newly discovered family can also act as Rho-GEFs. These CZH proteins include...
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Over the past decade, an increasing appreciation has developed for the role of small GTP-binding proteins (GTPases) as critical molecular switches. Small GTPases function as important regulators of multiple cellular processes by transducing signals from extracellular stimuli to intracellular effector pathways. The three primary members of the Rho family of GTPases include Rho, Rac, and Cdc42, w...
متن کاملRho GAPs and GEFs
Within blood vessels, endothelial cellâ€"cell and cellâ€"matrix adhesions are crucial to preserve barrier function, and these adhesions are tightly controlled during vascular development, angiogenesis, and transendothelial migration of inflammatory cells. Endothelial cellular signaling that occurs via the family of Rho GTPases coordinates these cell adhesion structures through cytoskeletal remo...
متن کاملStructural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).
The Dock180 family of atypical Rho family guanine nucleotide exchange factors (Rho-GEFs) regulate a variety of processes involving cellular or subcellular polarization, including cell migration and phagocytosis. Each contains a Dock homology region-1 (DHR-1) domain that is required to localize its GEF activity to a specific membrane compartment where levels of phosphatidylinositol (3,4,5)-trisp...
متن کاملSignalling by Rho family proteins.
Introduction The Rho family is part of the Ras superfamily of small GTP-binding proteins, and consists of Rho (A, B and C), Rac (1 and 2), two Cdc42 isoforms, RhoD, RhoE, RhoG, TClO and TTF [l]. Different members of the large Ras superfamily regulate a diverse array of cellular processes, from vesicle trafficking to signal transduction. They all have in common the ability to bind and hydrolyse ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2005
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.02671